Tournament organizers said Tuesday that the 31-year-old American withdrew for "personal reasons,'' without elaborating.
The French Open also said two other Americans had also pulled out: Meghann Shaughnessy will miss due to an injury to her left knee, while Meilen Tu is nursing a left hip injury.
Davenport's best singles finish on the Paris clay came when she reached the semifinals in 1998 - the same year she won the U.S. Open singles title. She won Wimbledon the next year and the 2000 Australian Open.
Davenport won the French Open doubles title with Mary Joe Fernandez in 1996.
The French Open starts Sunday.
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Safina withdraws from Italian Open with back injury
