Potito Starace also advanced, beating Marcos Daniel of Brazil 6-4, 6-4, and Juan Ignacio Chela of Argentina defeated Pablo Andujar of Spain 6-0, 3-6, 6-1.
"I think I played generally well today, and I still expect to improve to continue to advance in this tournament,'' said Chela, who is recovering from injury.
Also, Martin Vassallo Arguello of Argentina beat Oscar Hernandez of Spain 6-3, 7-6 (1) and Juan Monaco of Argentina beat Nicolas Devilder of France 6-2, 6-4.
Monaco reached the final in Vina del Mar last year but had to retire with an ankle injury, leaving the title to Fernando Gonzalez of Chile.
Monaco, Cuevas, Capdeville reach Chile quarters
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Gimeno-Traver, Starace win at Movistar Open