Nadal, who beat Roger Federer in last year’s final, beat Philipp Kohlschreiber of Germany 6-4, 6-2, 2-6, 7-5 in a night match. The Spaniard broke Kohlschreiber’s serve in the 11th game of the fourth set, then held serve to take the match with a forehand winner.
In the fourth round, Nadal will play Ivo Karlovic, who beat Ivan Ljubicic 6-3, 3-6, 6-3, 7-6 (7).
The fifth-seeded Murray, bidding to win his first Grand Slam singles title, beat Florent Serra of France 7-5, 6-1, 6-4 and is one victory away from a potential quarterfinal with Nadal.
First, Murray will have to beat American John Isner, winner of the Auckland tournament last week for his first ATP title. The 6-foot-9 Isner continued his strong form by beating 12th-seeded Gael Monfils of France 6-1, 4-6, 7-6 (4), 7-6 (5).
“I was just kind of riding a wave of momentum, and I still am,” Isner said. “Hopefully I can keep it going.”
No. 4 Del Potro beat Florian Mayer of Germany 6-3, 0-6, 6-4, 7-5 and No. 7 Roddick advanced 6-7 (4), 6-4, 6-4, 7-6 (3) over Feliciano Lopez of Spain.
Next up for del Potro is Marin Cilic, who beat Stanislas Wawrinka 4-6, 6-4, 6-3, 6-3.
Gonzalez, the 2007 finalist here, beat Evgeny Korolev of Kazakhstan 6-7 (5), 6-3, 1-6, 6-3, 6-4. Roddick and Gonzalez will play each other Sunday in the fourth round, with the American holding an 8-3 edge in career meetings, including a straight-sets win the last time they met in the round of 16 at the 2008 U.S. Open.
“It’s going to be tough,” Gonzalez said. “For sure I have to play better if I want to beat him.”
Gonzalez was supported Friday by a throng of noisy, flag-waving Chilean fans on Show Court 2. Korolev said it was like playing at a soccer match.
“It was exciting to play in front of this crowd ... big support far away from home,” Gonzalez said.
Roddick is wary.
“He’s a very dangerous player,” the 2003 U.S. Open champion said. “Some days he comes out, looks like he’s playing ping-pong the way he can sling the ball around. I don’t think there are going to be a lot of secrets out there.”
Also on NBCSports.com
NFL playoffs: Breakdowns AFC | NFC
Celizic: Everyone has something to lose — even Jets
Blyleven: Yankees, Red Sox will rule again in ’10
NBA: Any better MVP candidate than LeBron?
Twitter: Follow us @nbc_sports
Roddick booed at Aussie, Blake loses marathonPrimera Liga round-up