Zverev advanced to his first career final when No. 4 Richard Gasquet of France withdrew because of a fever.
Simon broke Kohlschreiber three times to reach his first final since winning on hard courts at Bangkok last year for his sixth career title.
Story continues below ↓advertisement | your ad hereSimon needed five sets to put away Kohlschreiber at the U.S. Open last month, but won this time without conceding a break chance in just 54 minutes.
The 23-year-old Zverev is the first qualifier to reach an ATP Tour final this season and the lowest-ranked finalist at 155.
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Fofana open to offersClijsters loses to Azarenka at Eastbourne