Roddick, who limped into the post-match news conference on Tuesday, quit after wasting a break point.
Roddick is vying for one of the final three spots at the season-ending ATP World Tour Finals in London next month. But the sixth-ranked Roddick says he's more concerned about taking care of his health than qualifying for the eight-man event.
The 22nd-ranked Wawrinka will play 13th-seeded Radek Stepanek of the Czech Republic in the third round.
Injury woe for UcheFederer pulls out of Japan Open, Shanghai Masters