The top-ranked Safina leads the women's U.S. Open field, ahead of No. 2 Serena Williams. Safina is 0-3 in Grand Slam tournament finals, while Williams is the defending champion at Flushing Meadows and has won 11 major championships.
Two-time U.S. Open winner Venus Williams is seeded No. 3, followed by Beijing Olympics gold medalist Elena Dementieva and 2008 U.S. Open runner-up Jelena Jankovic.
Maria Sharapova is seeded 29th. She won the 2006 U.S. Open for one of her three major titles, but missed the tournament last year because of a right shoulder injury. The Russian had surgery in October and a long absence from the tour dropped her ranking.
Five-time defending champion Federer is seeded No. 1 in New York for the fifth time. He is followed by new No. 2 Andy Murray, Rafael Nadal, Novak Djokovic and 2003 U.S. Open champion Andy Roddick.
The draw will be announced Thursday, and the tournament begins Monday.
Williams sisters, Clijsters lead U.S. Open fieldKeirrison open to Roma loan