Pennetta won only three games against Vinci at Barcelona three months ago, but this time broke her seven times to even their head-to-heads at 3-all.
Seventh-seeded Aravane Rezai of France also won her second-round match, overcoming Varvara Lepchenko of the United States 6-7 (2), 6-4, 6-2 in just under three hours at Country Time Club.
However, sixth-seeded Ekaterina Makarova of Russia fell to Olga Govortsova of Belarus 6-2, 6-2 in 44 minutes, and 2006 runner-up Tathiana Garbin of Italy ended the winning run of Maria Jose Martinez Sanchez of Spain 6-2, 6-3. Martinez Sanchez won the Swedish Open on Saturday.
Second-seeded Patty Schnyder, making her first appearance at Palermo since she won on debut as the top seed in 1998, defeated Russian teenager Anastasia Pivovarova 6-4, 6-0 to open her account. The Swiss veteran was coming off the final at Budapest.
Zokora targets Sevilla glorySchiavone advances to 2nd round in Prague