Nadal, attempting to become the first to win five straight French Open titles, extended his French Open record to 30-0 by beating Teimuraz Gabashvili of Russia 6-1, 6-4, 6-2.
“So what?” Nadal said of his accomplishment. “(I’m) happy for the record, but in the end happy for the result.”
Murray defeated Potito Starace of Italy 6-3, 2-6, 7-5, 6-4.
The top-seeded Nadal has never lost at Roland Garros, and his 30th straight win on the tournament’s red clay gives him the record for most consecutive wins.
Nadal was forced to save three break points in the first game of the match. He only had to save one more the rest of the way, winning in straight sets for the second match in a row.
Murray trailed 5-1 in the third set but broke Starace three straight times to win.
“On clay, there’s always time for you to get sort of back into the match and find your game, even if you’re struggling,” Murray said.
Murray also reached the third round at Roland Garros last year but lost to Nicolas Almagro in four sets. In his only other appearance at the French Open, in 2006, he lost in the first round.
No. 7 Gilles Simon of France, No. 8 Fernando Verdasco of Spain, No. 12 Fernando Gonzalez of Chile and No. 13 Marin Cilic of Croatia also advanced, but two-time Grand Slam champion Marat Safin and French veteran Fabrice Santoro played their last matches at Roland Garros.
Safin, who plans to retire after this season, fell to wild-card entry Josselin Ouanna of France in five sets 7-6 (2), 7-6 (4), 4-6, 3-6, 10-8.
Santoro, who has made a record 67 Grand Slam appearances, lost in the first round of this year’s French Open — his record-tying 20th — to Christophe Rochus of Belgium 6-3, 6-1, 3-6, 6-4.
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“Twenty years. That counts for something in a lifetime,” Santoro said. “It has been a long road, a fantastic career. I had a lot of fun and learned a lot.”
Santoro and Rochus started their match Tuesday, but it was suspended by darkness with the Belgian leading 5-3 in the fourth set. The pair came back out onto the court after Safina’s win and played only eight minutes.
No. 21 Dmitry Tursunov of Russia and No. 28 Feliciano Lopez of Spain also lost.
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